
Cape Girardeau Vacations
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Your Cape Girardeau Vacation
Food, history, entertainment and more … There's so much to immerse yourself in with a Cape Girardeau vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's memorable. If sightseeing is on the agenda during your trip to Cape Girardeau, swing by major attractions like Isle Casino Cape Girardeau, Cape Rock Park and Cape Girardeau Conservation Nature Center. Expedia will help you escape your routine. Tailor your vacation to Cape Girardeau to suit your travel style, whatever that may be.
Stay near popular Cape Girardeau attractions
Cape Girardeau Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $112 total per night from Nov 15 to Nov 16
$112 total
Nov 15 - Nov 16
Total with taxes and fees
9.6/10 Exceptional! (1,001 reviews)
"Best breakfast I’ve had in a long time at a hotel. The variety was nice too!"
Reviewed on Nov 4, 2026

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $81 total per night from Nov 9 to Nov 10
$81 total
Nov 9 - Nov 10
Total with taxes and fees
9.2/10 Wonderful! (1,000 reviews)
"Will stay again"
Reviewed on Nov 2, 2026

The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $119 total per night from Nov 11 to Nov 12
$119 total
Nov 11 - Nov 12
Total with taxes and fees
9.4/10 Exceptional! (701 reviews)
"Every time I stay here I truly enjoy my stay Clean rooms and staff is very attentive Will stay here again"
Reviewed on Nov 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Cape Girardeau Vacation Packages
Cape Girardeau Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Cape Girardeau Municipal Airport (CGI) |
Population | 39,500 |
Max Temp Winter | 45ºF |
Max Temp Summer | 85ºF |
Top Sights | Cape Splash Family Aquatic Center, Hunter Valley Winery and Steele Crest Winery |
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- Cape Rock Park
- Crown Valley Winery
- Dexter Vacations
- Cape Splash Family Aquatic Center
- Trail of Tears State Park
- The Heritage House
- Sikeston Depot Museum
- Bernie Vacations
- Hunter Valley Winery
- Southeast Missouri State University
- Hunter-Dawson State Historic Site
- Fort D Historic Site
- Stoddard County Civil War Memorial Cemetery
- Eden Spa & Salon
- Visit Cape Girardeau
- Lake Wappapello
- Central Park
- New Madrid Historical Museum
- Silver Mine Recreation Area
- Riverfront Bridge Park
- Charleston Vacations
- Litz Park
- Weingarten Vineyard
- Bloomfield Vacations
- Marble Hill Vacations
- National Shrine of Our Lady of the Miraculous Medal
- Marston Community Center
- Sikeston Vacations
- Perryville Vacations
- Felix Valle House State Historic Site
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.





















